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UEU » Journal » Farmasi
Posted by [email protected] at 15/01/2020 15:26:01  •  411 Views


EFFECTS OF THE METHANOL EXTRACTS PHALERIA MACROCARPA (SCHEFF) BOERL FRUITS ON ANGIOTENSIN CONVERTING ENZYME (ACE) ACTIVITY

Created by :
Aprilita Rina Yanti Eff ( 215020572 )
Maksum Radji   Abdul Munim



SubjectFARMASI
METANOL
Alt. Subject PHARMACEUTICAL
METHANOL
KeywordPHALERIA MACROCARPA

Description:

The present study was carried out to investigate the antihypertensive effect and Angiotensin Converting Enzyme activity of methanolic extract of Phaleria macrocarpa (Scheff) Boerl fruits in rats . Hypertension was induced experimentally by 10% w/v fructose diet ad libitum for 8 weeks. P. marcocarpa was given at the dose 0.5, 1 and 2 g/kg BW start at week 6 until week 8 and 1 g/kg BW for 8 weeks. Blood pressure was measured at baseline and at every weeks for 8 weeks using tail-cuff plethysmography. After completion of treatment schedule rats from each group were anesthetized with urethane (120 mg/100 gm, i. p.). Blood was collected and then centrifugated to obtain plasma and later store at-700C for analysis activity ACE plasma. The results suggests that methanol extract of Phaleria marcocarpha could prevent the development high blood pressure and normalized blood pressure in rat induced by diet rich in fructose. The results tend to suggest that methanol extracts of possesses antyhipertensive activity, through inhibition of angiotensin converting enzyme.

Contributor:
  1. FD Suyatna
Date Create:15/01/2020
Type:Text
Format:PDF
Language:Indonesian
Identifier:UEU-Journal-11_0085
Collection ID:11_0085


Source :
IJAPBC - Vol. 3(4), Oct - Dec, 2014

Relation Collection:
Fakultas Ilmu Kesehatan

Coverage :
Civitas Akademika Universitas Esa Unggul

Rights :
@2020 Perpustakaan Universitas Esa Unggul


Publication URL :
https://digilib.esaunggul.ac.id/effects-of-the-methanol-extracts-phaleria-macrocarpa-scheff-boerl-fruits-on-angiotensin-converting-enzyme-ace-activity-14173.html




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