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Posted by email@example.com at 27/05/2022 10:13:32 • 42 Views
ANTIHYPERTENSIVE AND ANTIOXIDANT ACTIVITY OF HERBAL MEDICINE (JAMU) B ON RATS INDUCED BY 10% FRUCTOSECreated by :
Aprilita Rina Yanti Eff ( 0318046802 )
Reza Ayu Pertiwi, Hermanus Ehe Hurit, Sri Teguh Rahayu, Yonatan Eden
|Alt. Subject : ||ANTIHYPERTENSIVE|
Prolonged fructose intake can activate the renin-angiotensin-aldosterone system and enhance oxidative
stress conditions, causing hypertension and hyperuricemia. This study aimed to determine the
antihypertensive and antioxidant activity of Jamu B on the activity of superoxide dismutase (SOD),
level of glutathione (GSH), and malondialdehyde (MDA) in the kidneys of Sprague Dawley rats
induced by 10% fructose. Thirty rats were divided into six groups. Groups B1-B3 were Jamu groups at
a dose of 0.12 g/kg BW (B1), 0.24 g/kg BW (B2), and 0.36 g/kg BW (B3); group C (positive control)
was given captopril 0.1 g/kg BW, group D (negative control) was given only 10% fructose, and group E
(normal control) was healthy rats. The 10% fructose was induced for eight weeks and the treatment was
given on the week 9th and 10th. Jamu B reduced systolic and diastolic blood pressure at all doses, but was
not significantly different from the normal control group (p>0.05). The SOD activity in groups B1, B2,
B3, and C was significantly different from the negative control group (p<0.05). However, GSH levels
only showed a significant difference between B2, B3, C, and the negative control group (p<0.05). The
MDA levels only showed a significant difference between B3 and the negative control group (p<0.05).
Jamu B at the dose of 0.12 g/kg BW, 0.24 g/kg BW, and 0.36 g/kg BW have antihypertensive and
antioxidant activity in the kidneys of rats induced by 10% fructose. Nevertheless, Jamu B at a dose of
0.36 g/kg BW was the most effective as an antihypertensive and antioxidant agent.
|Date Create||:||27/05/2022 |
Pharmaceutical Sciences and Research (PSR), 9(1), 2022, 42-50
Fakultas Ilmu-Ilmu Kesehatan
Civitas Akademika Universitas Esa Unggul
@2022 Perpustakaan Universitas Esa Unggul
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