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UEU » Journal » Farmasi
Posted by ayudya@esaunggul.ac.id at 27/05/2022 10:13:32  •  42 Views


ANTIHYPERTENSIVE AND ANTIOXIDANT ACTIVITY OF HERBAL MEDICINE (JAMU) B ON RATS INDUCED BY 10% FRUCTOSE

Created by :
Aprilita Rina Yanti Eff ( 0318046802 )
Reza Ayu Pertiwi, Hermanus Ehe Hurit, Sri Teguh Rahayu, Yonatan Eden



SubjectANTIHIPERTENSI
ANTIOKSIDAN
JAMU
Alt. Subject ANTIHYPERTENSIVE
ANTIOXIDANT
HERBAL MEDICINE
Keywordfructose
jamu
kidney
glutathione
malondialdehyde
superoxide dismutase

Description:

Prolonged fructose intake can activate the renin-angiotensin-aldosterone system and enhance oxidative stress conditions, causing hypertension and hyperuricemia. This study aimed to determine the antihypertensive and antioxidant activity of Jamu B on the activity of superoxide dismutase (SOD), level of glutathione (GSH), and malondialdehyde (MDA) in the kidneys of Sprague Dawley rats induced by 10% fructose. Thirty rats were divided into six groups. Groups B1-B3 were Jamu groups at a dose of 0.12 g/kg BW (B1), 0.24 g/kg BW (B2), and 0.36 g/kg BW (B3); group C (positive control) was given captopril 0.1 g/kg BW, group D (negative control) was given only 10% fructose, and group E (normal control) was healthy rats. The 10% fructose was induced for eight weeks and the treatment was given on the week 9th and 10th. Jamu B reduced systolic and diastolic blood pressure at all doses, but was not significantly different from the normal control group (p>0.05). The SOD activity in groups B1, B2, B3, and C was significantly different from the negative control group (p<0.05). However, GSH levels only showed a significant difference between B2, B3, C, and the negative control group (p<0.05). The MDA levels only showed a significant difference between B3 and the negative control group (p<0.05). Jamu B at the dose of 0.12 g/kg BW, 0.24 g/kg BW, and 0.36 g/kg BW have antihypertensive and antioxidant activity in the kidneys of rats induced by 10% fructose. Nevertheless, Jamu B at a dose of 0.36 g/kg BW was the most effective as an antihypertensive and antioxidant agent.

Date Create:27/05/2022
Type:Text
Format:pdf
Language:English
Identifier:UEU-Journal-11_2767
Collection ID:11_2767


Source :
Pharmaceutical Sciences and Research (PSR), 9(1), 2022, 42-50

Relation Collection:
Fakultas Ilmu-Ilmu Kesehatan

Coverage :
Civitas Akademika Universitas Esa Unggul

Rights :
@2022 Perpustakaan Universitas Esa Unggul


Publication URL :
https://digilib.esaunggul.ac.id/antihypertensive-and-antioxidant-activity-of-herbal-medicine-jamu-b-on-rats-induced-by-10-fructose-25342.html




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dismutase , fructose , glutathione , jamu , kidney , malondialdehyde , superoxide , superoxide dismutase



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