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UEU » Journal » Farmasi Posted by [email protected] at 12/01/2021 17:03:27 • 414 Views
EVALUASI EKSTRAK N-HEKSAN-ETANOL 70% TRIBULUS CISTOIDES DALAM SEDIAAN SUSPENSI TERHADAP SPERMATOZOA MENCIT (MUS MUSCULUS L.)EVALUATION OF N-HEXANE-70% ETHANOL EXTRACT TRIBULUS CISTOIDES IN SUSPENSION PREPARATION TOWARDS SPERMATOZOA MICE (MUS MUSCULUS L.)Created by :
Ayu Lestari ( none ) Aprilita Rinayanti
Subject: | SPERMATOZOA HORMON | Alt. Subject : | MUS MUSCULUS L. | Keyword: | MENCIT SPERMATOZOA |
Description:
Tanaman Tribulus cistoides berpotensi mengatasi gangguan reproduksi pada pria melalui
pengaturan hormon. Hormon testosteron yang berperan dalam meningkatkan libido juga
sangat berperan dalam proses pembentukan spermatozoa serta berperan dalam pematangan
spermatozoa di epididimis. Tujuan dari penelitian ini adalah mengevaluasi pemberian ekstraks
n-heksana etil alkohol 70% T. cistoides secara oral terhadap kualitas dan konsentrasi
spermatozoa mencit (Mus musculus L.) jantan Galur DDY yang telah diinduksi parasetamol.
Penelitian yang dilakukan bersifat eksperimental menggunakan Rancangan Acak Lengkap
(RAL). Kelompok uji terdiri dari kelompok kontrol menggunakan suspensi CMC 1% dan
kelompok perlakuan dengan pemberian suspensi ekstrak n-heksana-etil alkohol 70% T.
cistoides dosis 400; 800; 1600; dan 3200 mg/kgBB/hari selama tiga hari berturut-turut. Data
yang diperoleh dianalisa dengan uji ANAVA (α=0,05) menggunakan SPSS. Pemberian
suspensi ekstrak n-heksana-etil alkohol 70% T. cistoides berpengaruh dalam meningkatkan
konsentrasi spermatozoa sampai di atas tingkat normal, tetapi tidak berpengaruh terhadap
berat testis, persentase motilitas, dan persentase abnormalitas. Dalam kisaran dosis 400
mg/kgBB/hari sampai 3200 mg/kgBB/hari, semakin tinggi dosis ekstrak n-heksana-etil
alkohol 70% T. cistoides yang diberikan secara oral, konsentrasi spermatozoa yang dihasilkan
semakin besar.
Alt. Description
Tribulus cistoides plants have the potential to overcome reproductive disorders in men through
hormonal regulation. The hormone testosterone which plays a role in increasing libido is also
very important in the process of spermatogenesis and plays a role in the maturation of
spermatozoa in the epididymis. The aim of this study was to evaluate the administration of
Tribulus cistoides n-hexane-70% ethyl alcohol extract to the quality and concentration of
spermatozoa of male DDY mice (Mus musculus L.) that had been induced by paracetamol.
The research conducted was experimental using Completely Randomized Design (CRD). The
test group consisted of the control group using 1% CMC suspension and the treatment group
by giving suspension of n-hexane-70% ethyl alcohol extract T. cistoides dose 400; 800; 1600; and 3200 mg/kg/day, respectively for three consecutive days. The data obtained were analyzed
by ANAVA test (α = 0.05) using SPSS. The suspension of 70% T. cistoides n-hexane-ethylalcohol extract had an effect on increasing the concentration of spermatozoa to above the
normal level, but did not affect testicular weight, motility percentage, and percentageabnormalities. In the dosage range of 400 mg/kg/day to 3200 mg/kg/day, the higher the dose
of T. cistoides extract of n-hexane-70% ethyl alcohol given orally, the greater the
concentration of spermatozoa produced.
Date Create | : | 12/01/2021 | Type | : | Text | Format | : | pdf | Language | : | Indonesian | Identifier | : | UEU-Journal-11_0404 | Collection ID | : | 11_0404 |
Source : Archives Pharmacia Volume 1 Nomor 2, Juli 2019
Relation Collection: Fakultas Ilmu-Ilmu Kesehatan
Coverage : Civitas Akademika Universitas Esa Unggul
Rights : @2021 Perpustakaan Universitas Esa Unggul
Publication URL : https://digilib.esaunggul.ac.id/evaluasi-ekstrak-nheksanetanol-70-tribulus-cistoides-dalam-sediaan-suspensi-terhadap-spermatozoa--mencit-mus-musculus-l-17821.html
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