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UEU » Journal » Farmasi
Posted by [email protected] at 12/01/2021 17:03:27  •  356 Views


EVALUASI EKSTRAK N-HEKSAN-ETANOL 70% TRIBULUS CISTOIDES DALAM SEDIAAN SUSPENSI TERHADAP SPERMATOZOA MENCIT (MUS MUSCULUS L.)

EVALUATION OF N-HEXANE-70% ETHANOL EXTRACT TRIBULUS CISTOIDES IN SUSPENSION PREPARATION TOWARDS SPERMATOZOA MICE (MUS MUSCULUS L.)

Created by :
Ayu Lestari ( none )
Aprilita Rinayanti



SubjectSPERMATOZOA
HORMON
Alt. Subject MUS MUSCULUS L.
KeywordMENCIT
SPERMATOZOA

Description:

Tanaman Tribulus cistoides berpotensi mengatasi gangguan reproduksi pada pria melalui pengaturan hormon. Hormon testosteron yang berperan dalam meningkatkan libido juga sangat berperan dalam proses pembentukan spermatozoa serta berperan dalam pematangan spermatozoa di epididimis. Tujuan dari penelitian ini adalah mengevaluasi pemberian ekstraks n-heksana etil alkohol 70% T. cistoides secara oral terhadap kualitas dan konsentrasi spermatozoa mencit (Mus musculus L.) jantan Galur DDY yang telah diinduksi parasetamol. Penelitian yang dilakukan bersifat eksperimental menggunakan Rancangan Acak Lengkap (RAL). Kelompok uji terdiri dari kelompok kontrol menggunakan suspensi CMC 1% dan kelompok perlakuan dengan pemberian suspensi ekstrak n-heksana-etil alkohol 70% T. cistoides dosis 400; 800; 1600; dan 3200 mg/kgBB/hari selama tiga hari berturut-turut. Data yang diperoleh dianalisa dengan uji ANAVA (α=0,05) menggunakan SPSS. Pemberian suspensi ekstrak n-heksana-etil alkohol 70% T. cistoides berpengaruh dalam meningkatkan konsentrasi spermatozoa sampai di atas tingkat normal, tetapi tidak berpengaruh terhadap berat testis, persentase motilitas, dan persentase abnormalitas. Dalam kisaran dosis 400 mg/kgBB/hari sampai 3200 mg/kgBB/hari, semakin tinggi dosis ekstrak n-heksana-etil alkohol 70% T. cistoides yang diberikan secara oral, konsentrasi spermatozoa yang dihasilkan semakin besar.


Alt. Description

Tribulus cistoides plants have the potential to overcome reproductive disorders in men through hormonal regulation. The hormone testosterone which plays a role in increasing libido is also very important in the process of spermatogenesis and plays a role in the maturation of spermatozoa in the epididymis. The aim of this study was to evaluate the administration of Tribulus cistoides n-hexane-70% ethyl alcohol extract to the quality and concentration of spermatozoa of male DDY mice (Mus musculus L.) that had been induced by paracetamol. The research conducted was experimental using Completely Randomized Design (CRD). The test group consisted of the control group using 1% CMC suspension and the treatment group by giving suspension of n-hexane-70% ethyl alcohol extract T. cistoides dose 400; 800; 1600; and 3200 mg/kg/day, respectively for three consecutive days. The data obtained were analyzed by ANAVA test (α = 0.05) using SPSS. The suspension of 70% T. cistoides n-hexane-ethylalcohol extract had an effect on increasing the concentration of spermatozoa to above the normal level, but did not affect testicular weight, motility percentage, and percentageabnormalities. In the dosage range of 400 mg/kg/day to 3200 mg/kg/day, the higher the dose of T. cistoides extract of n-hexane-70% ethyl alcohol given orally, the greater the concentration of spermatozoa produced.

Date Create:12/01/2021
Type:Text
Format:pdf
Language:Indonesian
Identifier:UEU-Journal-11_0404
Collection ID:11_0404


Source :
Archives Pharmacia Volume 1 Nomor 2, Juli 2019

Relation Collection:
Fakultas Ilmu-Ilmu Kesehatan

Coverage :
Civitas Akademika Universitas Esa Unggul

Rights :
@2021 Perpustakaan Universitas Esa Unggul


Publication URL :
https://digilib.esaunggul.ac.id/evaluasi-ekstrak-nheksanetanol-70-tribulus-cistoides-dalam-sediaan-suspensi-terhadap-spermatozoa--mencit-mus-musculus-l-17821.html




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