ANTIOXIDANT EFFECTS OF METHANOLIC EXTRACT OF PHALERIA MACROCARPA (SCHEFF.) BOERL  IN FRUCTOSE 10%-INDUCED RATS

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UEU » Journal » Farmasi
Posted by [email protected] at 15/01/2020 15:02:13 • 427 Views

ANTIOXIDANT EFFECTS OF METHANOLIC EXTRACT OF PHALERIA MACROCARPA (SCHEFF.) BOERL IN FRUCTOSE 10%-INDUCED RATS

Created by :
Aprilita Rina Yanti Eff ( 215020572 )
Maksum Radji Abdul Mun�im

Subject:	FARMASI EKSTRAK METANOLIK
Alt. Subject :	PHARMACEUTICAL METHANOLIC EXTRACT
Keyword:	OXIDATIVE STRESS PHALLERIA MACROCARPA

Description:

The present study was carried out to investigate whether methanolic extract of Phalleria macrocarpa (Scheff) Boerl fruits (PM) mitigates oxidative stress in fructose fed rats. Male Sprague Dawley rats were fed with fructose 10% w/v ad libitum for 8 weeks. The rats (n = 36) were divided into six groups (of six each); normal control, negative control, captopril 10 mg/kg BW and extract methanolic P. Marcocarpha (PM)at the dose0.5, 1, 2 g/kg BW, were given start at week 6 until week 8 and 1 g/kg BW were given for 8 weeks. After completion of treatment schedule rats from each group were anesthetized with urethane (120 mg/100 gm, intraperitoneal). Blood was collected and then centrifugated to obtain plasma and later store at-70 0 C. Plasma glucose, lipid peroxidation markers and antioxidant enzyme (MDA, GSH, and SOD) were analyzed in all the groups. Fructose consumption increased SOD and glucose plasma level and reduced GSH and SOD activity, whereas these levels were near-normal in the rats consuming PM and captopril.

Contributor	:	FD Suyatna
Date Create	:	15/01/2020
Type	:	Text
Format	:	PDF
Language	:	Indonesian
Identifier	:	UEU-Journal-11_0084
Collection ID	:	11_0084

Source :
International Journal of PharmTech Research Vol.8, No.9, pp 41-47, 2015

Relation Collection:
Fakultas Ilmu Kesehatan

Coverage :
Civitas Akademika Universitas Esa Unggul

Rights :
@2020 Perpustakaan Universitas Esa Unggul

Publication URL :
https://digilib.esaunggul.ac.id/antioxidant-effects-of-methanolic-extract-of-phaleria-macrocarpa-scheff-boerl--in-fructose-10induced-rats-14169.html

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