IN-VITRO Α-GLUCOSIDASE INHIBITORY ACTIVITY OF LITSEA PETIOLATA HK. F

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UEU » Proceeding » Farmasi
Posted by [email protected] at 22/04/2022 10:03:13 • 437 Views

IN-VITRO Α-GLUCOSIDASE INHIBITORY ACTIVITY OF LITSEA PETIOLATA HK. F

Created by :
Neneng Siti Silfi Ambarwati ( none )
Berna Elya2; Putu Gita Maya Widyaswari Mahayasih (0318089202); Muhamad Sharul Nizam Awang; Hanita Omar; Islamudin Ahmad; Dwi Atmanto

Subject:	ENZIM OBAT SINTETIK OBAT-OBATAN ALAMI
Alt. Subject :	ENZYME SYNTHETIC DRUGS NATURAL MEDICINE
Keyword:	Litsea petiolata Hk. F extract fraction alpha-glucosidase inhibitory

Description:

Alpha-glucosidase is an enzyme that plays a role in the process of hydrolysis of carbohydrates into glucose so that the enzyme inhibitor can inhibit the process of glucose absorption. One synthetic drug that has a mechanism of action to inhibit the activity of the alpha-glucosidase enzyme is acarbose, however in the long term has side effects, such as digestive system disorders. Therefore, the use of natural medicines as alternative therapies can be considered for use. This study aimed to determine the inhibitory activity of the enzyme alpha-glucosidase from extracts and fractions of Litsea petiolata Hk. f bark. The extraction method used maceration, and fractionation using column chromatography. The results showed that the IC50 values for extract, fraction B, fraction D, and acarbose were 444.17 μg/ml, 682.85 μg/ml, 1683.45 μg/ml, and 110.60 μg/ml, respectively. In conclusion, the activity extract as the alpha-glucosidase was higher than the fractions but lower than acarbose.

Date Create	:	22/04/2022
Type	:	Text
Format	:	pdf
Language	:	English
Identifier	:	UEU-Proceeding-14_0259
Collection ID	:	14_0259

Source :
Proceedings of the 1st International Conference on Health Science, ICHS 2020, 26-27 October 2020, Jakarta, Indonesia

Relation Collection:
Fakultas Ilmu-ilmu Kesehatan

Coverage :
Civitas Akademika Universitas Esa Unggul

Rights :
@2022 Perpustakaan Universitas Esa Unggul

Publication URL :
https://digilib.esaunggul.ac.id/invitro-913glucosidase-inhibitory-activity-of-litsea-petiolata-hk-f-24865.html

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