IN-VITRO AND IN-VIVO SUNSCREEN ACTIVITY OF ACTIVE COMPOUNDS ISOLATED FROM FRUITS OF PHALERIA MARCOCARPHA (SCHEFF.) BOERL

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UEU » Journal » Farmasi
Posted by [email protected] at 15/01/2020 12:44:08 • 884 Views

IN-VITRO AND IN-VIVO SUNSCREEN ACTIVITY OF ACTIVE COMPOUNDS ISOLATED FROM FRUITS OF PHALERIA MARCOCARPHA (SCHEFF.) BOERL

Created by :
Dr. APRILITA RINA YANTI EFF, M.Biomed, Apt ( 215020572 )
Dra. RATIH DYAH PERTIWI, M.Farm, Apt IRVANI RAKHMAWATI, S.Si, M.Si

Subject:	SENYAWA AKTIF PHALERIA MARCOCARPHA
Alt. Subject :	ACTIVE COMPOUND PHALERIA MARCOCARPHA
Keyword:	MAHKOSIDE A PHALERIA MARCOCARPHA

Description:

Objective: Mahkota dewa fruits (Phaleria marcocarpha (Scheff.) Boerl) have been found to contain benzophenone and xanthone derivatives which have a protective effect against ultraviolet light. This study was aimed to evaluate the sunscreen activities of mahkoside A, mangiferin and 6, 4-dihydroxy4-methoxybenzophenone-2-O-β-D-glucopyranoside (6, 4-DHMP) isolated from Mahkota dewa fruits in-vitro and in-vivo. Methods: In-vitro�sunscreen activity was evaluated using spectrophotometric method by measuring percentage transmission of erythema, percentage transmission of pigmentation and sun protection factor (SPF). The sunscreen activity assays in-vivo was conducted by observing the effect of erythema in rats after exposed to an exotera lamp for 24 h. Results: In-vitro assays showed that mah- koside A, mangiferin and 6, 4-dihydroxy-4-methoxybenzophenone-2-O-β-Dglucopyranoside at a concentration of 100 ppm had SPF value of 3.44, 2.82 and 3.08 respectively. In-vivo test results showed that mangiferin at concentrations of 12.5%, 25%, and 50% decreased the amount of erythema and erythema diameter significantly different than negative control (p <0.05). Conclusion: Mahkoside A, mangiferin and 6, 4-DHMP possessed sunscreen activity in-vitro and in-vivo.

Contributor	:	TYAS PUTRI UTAMI, S.Pd, M.Biomed
Date Create	:	15/01/2020
Type	:	Text
Format	:	PDF
Language	:	Indonesian
Identifier	:	UEU-Journal-11_0072
Collection ID	:	11_0072

Source :
J Young Pharm, 2018; 10(2) Suppl: s106-s110

Relation Collection:
Fakultas Ilmu Kesehatan

Coverage :
Civitas Akademika Universitas Esa Unggul

Rights :
@2020 Perpustakaan Universitas Esa Unggul

Publication URL :
https://digilib.esaunggul.ac.id/invitro-and-invivo-sunscreen-activity-of-active-compounds-isolated-from-fruits-of-phaleria-marcocarpha-scheff-boerl-14156.html

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